Overall, the classic psychedelics, like magic mushrooms or truffles, LSD, and DMT, are among the safest drugs. Even safer than alcohol, weed, and tobacco.
These substances are not addictive in the traditional sense of the word. You cannot become physically dependent on them. But as with everything, it’s wise not to go overboard. Psychedelics can make you feel really good. Something we all want. Therefore, see it as a powerful, but temporary tool.
People with bipolar disorder may benefit from microdosing during the depressive phase, but better not microdose during a manic phase as the mania can be intensified.
In people with anxieties, microdosing can intensify the anxieties. And in people with paranoia symptoms, the paranoia and suspicion can increase.
Check out this information from the Global Commission on Drug Policy.